LOCATION: University of Limerick CLOSING DATE 04-August-2020 12:00
REPORTS TO: Project Leader
CONTRACT TYPE: Specific Purpose
SALARY SCALE: €37,874 – €49,048 p.a. pro rata (maximum starting salary € 42,559 p.a. pro rata)
- A doctoral degree (level 10 NFQ) in physics, chemistry, chemical engineering or related discipline (applicants who have met all requirements for graduation and are awaiting award will be considered. Please give date of Viva)
OVERALL PURPOSE OF THE JOB:
The Pharmaceutical Manufacturing Technology Centre (PMTC) is an industry led, industry driven research centre.
The research activities within are centred around three strategic areas;
- Cleaning – including containment, changeover, and validation
- Process control and optimisation
- Applied data utilisation/analytics
Pharmaceutical cleaning and subsequent verification and validation have always been a time consuming and costly operation in multipurpose pharmaceutical plants. It has a significant impact on plant efficiency, utilities, and resources. About 50% of time is spent doing cleaning, resulting in a massive impact on downtime, costs, and changeovers. The core cleaning project aims to build an experimental rig to mimic the cleaning process and to address some of the challenges that the pharmaceutical industry faces in cleaning by investigating and researching specific areas of cleaning. To achieve these goals, the research activities of this project are focused on three parts: (1) Computational fluid dynamics (CFD) modelling to quantify and predict cleaning rates by various cleaning methods and cleaning agents as a function of operating conditions, (2) Selection of the best cleaning agents using COSMO-RS modelling, experimental solubility and cleaning trials, (3) Online PAT solution for cleaning monitoring and verification.
A postdoctoral researcher is required to join the cleaning team to work on the development and implementation of Process Analytical Technology (PAT) tools for cleaning verification (part 3). The successful candidate will work closely with the other team members in areas 1 and 2. The successful candidate is expected to spend some of their time at industrial partners’ sites.
The project will provide opportunities for the successful candidate to have a broad impact on PAT implementation in the pharmaceutical industry and obtain excellent industry exposure.
Through its extensive industry network, PMTC conducts innovative, high quality research in
pharmaceutical manufacturing that has direct relevance to industry. The successful applicant will
be expected to interact with other PMTC researchers and liaise with the key industry stakeholders
on a regular basis.
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