Continuous Revolutions: Disrupting the Pharmaceutical Manufacturing Paradigm ABSTRACT Unfortunately, both the cost and supply gaps of medicine are increasing. There are on average 200 active drug shortages nationally each year. Lengthy supply chains, limited numbers of manufacturers (commodity chemicals and drug product), and surges in demand are some of the more prominent causes of drug shortages. This lack of responsiveness, uncertainty, and diversity create pressure for drug suppliers, hosp...

Physical Multiscale Fatigue Modeling from Atoms to Components without Experiments ABSTRACT In this presentation, the first successful examples of real multiscaling from atoms to macroscale for different applications for metals will be outlined. Multiscale simulation comprises all length scales from electrons/atoms via micromechanical contributions to macroscopic materials behavior and further up to applications for components, frequently called multiscale materials modelling (MMM) (Fig. 1). ...

Science & Engineering/ESB Visiting Lecture Series The Connection between the Land and Energy Sector in Meeting Green House Gas (GHG) Mitigation Targets: Considering Local Conditions for Meeting Global Goals (To reserve a place email: eileen.madden@ul.ie  Light refreshments will be served at 4.30pm) Abstract Meeting the GHG emission reduction targets agreed upon in Paris agreement will be an immense challenge for all countries. It requires immediate action to decarbonize the vari...

Photonic Professional GT2: Highest resolution 3D printing in research and prototyping” The achievements of the two-photon polymerization based world’s highest resolution 3D micro-printer will be presented. The device offers a defined control on the feature sizes and resolutions ranging from nanometer to micrometer scale and accessible print area of ~ cm2. Subsequently, the printed structures can be transferred into metal, semiconductors or ceramics by electro-plating or coating techniques. ...

D-Life: The Importance of Proteome Homochirality Maintenance and Underlying Mechanisms Homochirality is one of the key principles of life. Our proteins are composed of homochiral monomers, exclusively of L-amino acids (L-AAs), while D-amino acids (D-AAs) are thought to be non-proteinogenic. This is crucial because enzymes have stereo selective binding modes and therefore, do not cooperate with proteins partially or fully consist of D-amino acids. Recent advances demonstrate that various stre...

Bernal Industry Day ‘Collaboration, Leadership and Support’   Keep up to date with the latest research in materials science, technology and R&D funding available to industry by speaking to the experts themselves at the Bernal Industry Day. Speakers include; • World leading Materials Scientists • Representatives from Europe’s Research and Development Funders, Science Foundation Ireland, Enterprise Ireland, Horizon 2020 • Keynote speech by Marcus Horan, Munster Rugby, I...

Immunotherapy in Oncology and Addressing the Challenges with Combination Strategies ABSTRACT Immune checkpoint blockade (ICB) therapies, such as the ones targeting cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) or programmed cell death protein 1 (PD-1), have displayed durable clinical responses in various cancers and are now approved by the FDA for a growing list of cancer types. Although these new immunotherapies have had a notable effect on cancer treatment, they only benefit a limited...

Sustainable Carbon Materials and their Composites ABSTRACT Multifunctional nanostructured materials are finding application in a range of sectors such as energy production and storage, catalysis, sensing and biomedicine. Advanced carbon materials possess unique properties such as: high electrical conductivity, high chemical and thermal stability, low toxicity, and ease of chemical functionalisation. However, the vast majority of their synthetic routes involve petroleum based materials. This is...

The audience will be introduced to the general area of optical spectroscopy, then specifically Raman, its theoretical underpinning and positioning in respect to other forms of optical spectroscopy, highlighting Raman’s advantages that have led to its ever-expanding utilisation in a multitude of fields. Associated Data Science techniques will also be touched upon. This will be followed by an introduction to Advanced Nano Technologies small volume-drop Raman Flipper Spectrometer, outlining the b...

Selective Brain Region Vulnerability in Parkinson’s Disease is Governed by α-Synuclein Conformations Neuronal aggregates of alpha-synuclein (αSyn) (Lewy bodies and neurites) are a pathological hallmark of Dementia with Lewy Bodies (DLB) and Parkinson’s disease (PD). It has recently been discovered that αSyn, a neuronal protein of unclear physiological function, normally exists in cells and brain tissue principally as α-helically folded multimers that resist pathological aggregation. It ...