The PMTC hosted an outstanding seminar by Professor Elizabeth M Topp, titled Solid-state Hydrogen Deuterium Exchange (ssHDX-MS) in the Development of Lyophilized Protein Formulations at the Bernal Institute on October 16th.
Elizabeth is a Professor in the Department of Industrial and Physical Pharmacy at Purdue University in West Lafayette, Indiana; and has also lately joined NIBRT as Chief Scientific Officer (CSO). She delivered a very interesting lecture on solid-state hydrogen deuterium exchange with mass spectrometric analysis (ssHDX-MS) in the development of lyophilized protein formulations. Her group in Purdue has developed ssHDX-MS as a novel analytical method for proteins in lyophilised solids, providing high resolution information on protein structure and matrix interactions. In her presentation, SSHDX-MS was shown to be highly correlated with the storage stability of various formulations of myoglobin (Mb) and of a monoclonal antibody (mAb). ssHDX-MS thus shows promise as a stability-indicating method that could help accelerate the development of Iyophilised protein drugs.
We warmly welcome Liz to Ireland and look forward to working with her on future projects and having her visit UL again soon