Process Engineering Cluster
While the shift from batch to continuous manufacturing remains topical in the pharmaceutical and other specialty sectors, fully continuous processing streams, from reaction to tablet, have yet to be realized. Advances in continuous upstream processes, such as flow chemistry, and continuous crystallization remain decoupled from advances in downstream formulation, and key limitations exist for both aspects. Moreover, there are limited suitable options available for continuous isolation and drying at pharmaceutical relevant scales and in pharmaceutical environments (containment, cleaning and ATEX). On the downstream side, continuous feeding of powders at low feed rates is challenging, and the exact mechanism of particle-particle interactions in some unit operations is not fully understood. On a broader perspective the mechanics of coupling unit operations together and coordinating inlet and outlet flows is not trivial, and there is currently a lack of mechanical and mathematical modelling expertise in this area. Process analytical technology and process modelling would be used to maximise process understanding and control process outputs.