Analog Devices Building,
University of Limerick.
+353 61 237738
B.Sc. (Hons) in Biochemistry,
Ph.D. in Chemical Engineering (University of Lisbon)
Research and Teaching Interests
- The development of particle engineering technologies for small and large molecule APIs (Active Pharmaceutical Ingredients), with a particular emphasis in (bio)pharmaceutical nanomanufacturing, which includes:
- Pharmaceutical processing for large molecule APIs (biopharmaceuticals):
Isolation and stabilization of biopharmaceuticals using spray drying and freeze drying
Engineering and manufacturing of biopharmaceutical nanoparticles
- Pharmaceutical processing for small molecule APIs (pharmaceuticals):
Continuous crystallization and drying of drug nanoparticles
Supercritical Co2 processing for polymorphic control
Luis Padrela is a lecturer in Industrial Biochemistry within the Department of Chemical Sciences and a Researcher at the Synthesis and Solid State Pharmaceutical Centre (SSPC) within the Bernal Institute. Luis studied Biochemistry at undergraduate level before obtaining his PhD in Chemical Engineering at the University of Lisbon (Portugal). Following his PhD, Luis worked in the pharmaceutical industry for almost 2 years (Hovione FarmaCiência, Portugal) before joining SSPC in UL as a postdoctoral researcher and as a senior research fellow later on.
Luis worked on different research projects in different institutions (academia and industry) and countries (Ireland, Portugal and Sweden) focusing his research on Particle Engineering Technologies, Continuous Nanocrystallization and (Bio)Pharmaceutical Processing. He has developed industrial expertise in Quality by Design, scale-up methods and particle engineering technologies for small and large molecule APIs with particular emphasis to spray drying of biopharmaceuticals. Luis has worked within the highest standards of quality (GLP, GMP) in the industry and participated in the development of several spray drying and nanosizing processes for oral and parenteral dosage forms.
Formation of indomethacin–saccharin cocrystals using supercritical fluid technology
L Padrela, MA Rodrigues, SP Velaga, HA Matos, EG de Azevedo
European Journal of Pharmaceutical Sciences 38 (1), 9-17
Screening for pharmaceutical cocrystals using the supercritical fluid enhanced atomization process
L Padrela, MA Rodrigues, SP Velaga, AC Fernandes, HA Matos, …
The Journal of Supercritical Fluids 53 (1-3), 156-164