Analog Devices Building,
University of Limerick.
+353 61 237756
M.Sc. in Biology and Ph.D. in molecular medicine
Research and Teaching Interests
Synaptopathies as a key feature of neurodevelopmental diseases
How genetic and non-genetic factors contribute to neuronal dysfunction
Developing novel research and treatment strategies using nanotechnology
Dr Grabrucker received his MSc in Biology with a focus on genetics in 2005 from the Technical University of Munich, Germany. From 2005 to 2009 he investigated the molecular mechanisms of synaptic plasticity in his doctoral at Ulm University, Germany. After receiving his Ph.D., he continued his neuroscientific research in the United States at Stanford University’s Department of Psychiatry and Behavioral Sciences until 2011. In 2011, he returned to University of Ulm as Assistant Professor, where he headed the research group “Molecular analysis of synaptopathies”. At the same time he took up the position of Executive Director of the Neurocenter of the University of Ulm. Since 2017, he is lecturer at the Department of Biological Sciences, at the University of Limerick.
Dr Grabrucker’s major research focus is in the area of translational neuroscience. He has secured funding of more than 987,000 EUR in the last 5 years from German national (DAAD, State of Baden Wuerttemberg, Ulm University), industrial (Ratiopharm, Zinpro Inc.) and private foundations (Else Kroener Fresenius Foundation, Alzheimer’s Association) sources. He participates in research networks such as the EU funded “Zinc-Net”, a network to foster research in the field of zinc biology. Dr Grabrucker serves as an expert reviewer for the Deutsche Forschungsgemeinschaft (DFG), Agence Nationale de la Recherche (ANR), Swiss national Science Foundation (SNF), National Science Center, Poland, and the European Commission, and is on the editorial board of several journals. He is an invited guest speaker in meetings worldwide. Since his PhD in 2009, he has published over 40 articles in peer reviewed journals, among them EMBO J, Nature, Brain, Journal of Neuroscience, and Journal of Controlled Release and 8 book chapters with a total impact factor of more than 200 and over 997 citations.
1. Tosi G, Vilella A, Schmeisser MJ, Boeckers TM, Ruozi B, Vandelli MA, Forni F, Zoli M, Grabrucker AM: Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to-cell transport. Journal of Controlled Release 2014; 177C: 96-107.
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2. Grabrucker S, Jannetti L, Eckert M, Gaub S, Chhabra R, Pfaender S, Mangus K, Reddy PP, Rankovic V, Schmeisser MJ, Kreutz MR, Ehret G, Boeckers TM, Grabrucker AM: Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain 2014; 137 (Pt 1): 137-152.
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